Population Pharmacokinetics of Methotrexate in Egyptian Children with Lymphoblastic Leukemia
نویسندگان
چکیده
منابع مشابه
Medium and High-Dose Methotrexate-Induced Toxicity in Children with Acute Lymphoblastic Leukemia
Background: Methotrexate has an important role in treatment of acute leukemia. We measured methotrexate level in CSF and blood of children with acute lymphoblastic leukemia to determine complications and outcomes. Materials and Methods: One hundred and twenty patients (73 male, 47 female), with mean age at diagnosis of 6.1 years (11mo_15years) entered the study. Patients were divided into two...
متن کاملMonitoring and treatment of acute kidney injury in children with acute lymphoblastic leukemia after high dose methotrexate chemotherapy
Abstact：objective To investigate acute kidney injury (AKI) in children with acute lymphoblastic leukemia (ALL) who received high dose methotrexate (MTX) chemotherapy and explore the corresponding treatment. Methods 180 children who received high dose MTX chemotherapy were observed with serum MTX concentration and serum creatinine. Patients with AKI of stage 3 or poor response to conventional tr...
متن کاملMonitoring and treatment of acute kidney injury in children with acute lymphoblastic leukemia after high dose methotrexate chemotherapy
Abstact：objective To investigate acute kidney injury (AKI) in children with acute lymphoblastic leukemia (ALL) who received high dose methotrexate (MTX) chemotherapy and explore the corresponding treatment. Methods 180 children who received high dose MTX chemotherapy were observed with serum MTX concentration and serum creatinine. Patients with AKI of stage 3 or poor response to conventional tr...
متن کاملMethotrexate Induced Encephalopathy in Acute Lymphoblastic Leukemia in Omani Children
Survival rates for children with leukemia have increased dramatically over the past few decades. Development of new chemotherapeutic agents and expanded use of older agents have had a major impact on outcome. Methotrexate (MTX) was one of the first drugs discovered to have significant activity against leukemia and still continues as a major component of treatment for acute lymphoblastic leukemi...
متن کاملAcute lymphoblastic leukemia: are Egyptian children adherent to maintenance therapy?
UNLABELLED BACKGROUND, AIMS, SETTINGS AND DESIGN: Poor adherence to oral maintenance chemotherapy can cause relapse of acute lymphoblastic leukemia (ALL). A multicenter study for the evaluation of adherence to oral 6-mercaptopurine (6-MP) maintenance chemotherapy for childhood ALL in Egypt to identify contributing factors and possible steps to promote adherence. MATERIALS AND METHODS The stud...
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ژورنال
عنوان ژورنال: Pharmacology & Pharmacy
سال: 2013
ISSN: 2157-9423,2157-9431
DOI: 10.4236/pp.2013.42020